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KMID : 1147520230160020121
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Korean Academy of Basic Medicine & Health Science
2023 Volume.16 No. 2 p.121 ~ p.127
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The Association between Impaired Fasting Glucose and Hyperuricemia According to Obesity Status: A Cross-Sectional Study
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Kim Dae-Hyun
Jeon Joo-Eun
Lee Min-Young
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Abstract
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We had aim to investigate associations with hyperuricemia for impaired fasting glucose (IFG), which represents the pre-diabetes stage among Korean general population based on a cross-sectional study. The base data of this study is from Korean National Health and Nutrition Examination Survey (2016-2021) containing to 22,336 participants aged 19 years or older. Among 22,336 participants who had not diagnosis for type 2 diabetes, 19,784 (88.6%) were in the hyperuricemia group and 2,552 (11.4%) were in the non-hyperuricemia group, and the serum uric acid (SUA) level in the hyperuricemia group was 7.6 mg/dL. (SD=0.9), which was higher than non-hyperuricemia (4.8 mg/dL, SD=1.1). The hyperuricemia group ad significant 1.23-odds ratio (OR; 95% CI: 1.23-1.23) for impaired glucose tolerance (IFG) compared with the non-hyperuricemia group in a multivariable logistic regression model adjusted for covariates. These association was higher in men than in women (OR=1.16, 95% CI: 1.16-1.17 for men; OR=1.35, 95% CI: 1.35-1.35 for women). There was a significant interaction effect between serum uric acid level and obesity status (p<0.0001). Among the Korean general population without a history of diabetes diagnosis, a significant relationship was confirmed between hyperuricemia and IFG, and there was a significant interaction between hyperuricemia and obesity states. Hyperuricemia increases morbidity and mortality in patients with type 2 diabetes, and since chronic diseases are caused by complex and diverse risk factors, in-depth research on hyperuricemia and chronic diseases is needed in the aging age.
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KEYWORD
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Uric acid, Hyperuricemia, Type 2 diabetes, Obesity
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